Product Catalog — Synthesis Routes

Database of 59 click chemistry compounds with 934 synthesis routes sourced from Reaxys. Each entry includes reaction conditions, yields, and literature DOI references.

Sulfonyl Fluorides (7) Azides & Alkyne Building Blocks (22) Triazole Ligands & Catalysts (3) Fluorinated Intermediates (2) Other Click Chemistry Reagents (25)

Sulfonyl Fluorides 7

Sulfonyl fluorides are key building blocks in Sulfur(VI) Fluoride Exchange (SuFEx) click chemistry — one of the most robust click reactions introduced by Sharpless and colleagues.

CASCompound NameFormulaMWRoutesRefs
1780694-70-3 5-chloropyridine-2-sulfonyl fluoride C5H3ClFNO2S 195.602 3 4
1934460-95-3 5-(5-amino-3-((4-(dimethylcarbamoyl)phenyl)amino)-1H-1,2,4-triazole-1-carbonyl)-2-fluorobenzenesulfonyl fluoride C7H4F2O4S 222.169 2 2
2393030-89-0 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl fluoride C12H16BFO4S 286.132 21 19
349-89-3 p-chlorobenzenesulfonyl fluoride C6H4ClFO2S 194.614 50 105
402-27-7 3-cyanobenzenesulfonyl fluoride C7H4FNO2S 185.179 9 10
52200-99-4 2-fluoro-benzenesulfonyl fluoride C6H4F2O2S 178.159 36 86
52201-01-1 4-(trifluoromethyl)benzenesulfonyl fluoride C7H4F4O2S 228.167 16 141

Azides & Alkyne Building Blocks 22

Azides and alkynes are the foundational reagents of copper-catalyzed azide-alkyne cycloaddition (CuAAC) — the quintessential click reaction that yields 1,2,3-triazole linkages with near-perfect regioselectivity.

CASCompound NameFormulaMWRoutesRefs
129392-86-5 tert-butyl (5-azidopentyl)carbamate C10H20N4O2 228.294 50 20
1309457-02-0 (S)-2-(4-(1-(26-azido-3,6,9,12,15,18,21,24-octaoxahexacosanyl)piperidin-4-yl) butyramido)-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxoprop-2-yl)-3-methylbutyramide C25H43N3O11S 593.696 10 17
1310686-23-7 C24H51MgN11O3S(2+) C9H16N4O3S 260.317 4 4
180695-80-1 tert-butyl 4-azidopiperidine-1-carboxylate C10H18N4O2 226.279 50 315
1820717-35-8 2-(2-azidoethoxy)acetic acid C8H15N3O3 201.225 11 13
201467-81-4 14-azido-3,6,9,12-tetraoxatetradecanoic acid C10H19N3O6 277.277 31 138
2062663-64-1 N-(1-(4-((20-azido-3,6,9,12,15,18-hexaoxaicosyl)oxy)phenyl)butyl)-2-methylpropane-2-sulfinamide C14H28BrN3O6 414.297 12 11
2110448-98-9 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl (2,5-dioxopyrrolidin-1-yl) carbonate C13H20N4O8 360.324 5 3
217180-81-9 17-azido-3,6,9,12,15-pentaoxaheptadecanoic acid C12H23N3O7 321.331 27 57
252378-68-0 tert-butyl {2-[2-(2-azidoethoxy)ethoxy]ethoxy}carbamate C11H22N4O5 290.319 50 52
252881-73-5 tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate C13H25N3O5 303.359 50 230
2761446-55-1 1-(17-azido-3,6,9,12,15-pentaoxaheptadecyl)-1H-imidazole C15H27N5O5 357.41 9 5
349553-73-7 6-azido-hexylamine C6H14N4 142.204 50 170
356046-26-9 1,17-diazido-3,6,9,12,15-pentaoxaheptadecane C12H24N6O5 332.36 6 132
361543-08-0 1,2-Bis-{2-[2-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethane C26H52N6O12 640.732 12 2
40139-55-7 3-amino-propionic acid ethyl ester C5H9N3O2 143.145 20 43
80667-36-3 12-azidododecanoic acid C12H23N3O2 241.334 15 61
880129-82-8 20-azido-3,6,9,12,15,18-hexaoxaicosan-1-oic acid C14H27N3O8 365.384 11 42
911209-07-9 tert-butyl (17-amino-3,6,9,12,15-pentaoxaheptadecyl)carbamate C17H34N4O7 406.48 30 24
932741-12-3 N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-2-bromoacetamide C8H15BrN4O3 295.136 3 2
945550-23-2 succinimidyl 8-azido-3,6-dioxaoctanoate C10H14N4O6 286.244 1 8
950683-55-3 tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate C11H22N4O4 274.32 11 56

Triazole Ligands & Catalysts 3

Triazole-containing ligands are specialized additives designed to accelerate and stabilize Cu(I)-catalyzed click reactions.

CASCompound NameFormulaMWRoutesRefs
1341215-17-5 BTTP C20H34N10O 430.556 2 33
206265-96-5 tert-butyl (23-(4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-3,6,9,12,15,1 8,21-heptaoxatricosyl)carbamate C21H42N4O9 494.586 4 3
760952-88-3 THPTA C18H30N10O3 434.501 25 143

Fluorinated Intermediates 2

Fluorinated intermediates play important roles in modern synthetic chemistry, serving as building blocks for pharmaceutical compounds, agrochemicals, and materials.

CASCompound NameFormulaMWRoutesRefs
1824194-78-6 3-Fluorsulfonyl-2-methyl-benzoesaeure C8H7FO4S 218.206 1 1
33866-06-7 3-Methyl-4-fluorsulfonylbenzoesaeure C8H7FO4S 218.206 1 2

Other Click Chemistry Reagents 25

This category encompasses diverse reagents used across various click chemistry reactions, including activated esters, Michael acceptors, epoxides, and multi-functional building blocks.

CASCompound NameFormulaMWRoutesRefs
112888-76-3 tert-butyl 4-[N-[2-acetoxymethyl-7-chloro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate C14H17NO2 231.294 37 16
1207355-31-4 dibenzazepine glutarylamino tetraethylene glycol acetyl pipecolate methyl ester C20H17NO3 319.36 12 196
1263166-90-0 (1R,8S,9S)-bicyclo[6.1.0]non-4-yn-9-ylmethyl (4-nitrophenyl) carbonate C10H14O 150.221 3 755
126422-58-0 4,7,10,13-tetraoxahexadeca-1,15-diyne C12H18O4 226.273 3 60
132178-37-1 2,5-dioxopyrrolidin-1-yl pent-4-ynoate C9H9NO4 195.175 9 378
1394136-25-4 C58H77N3O18Si C32H40N2O8 580.678 3 8
1418217-95-4 DIBAC-biotin C28H30N4O3S 502.637 3 6
1608140-48-2 C34H54N2O14 C34H54N2O14 714.808 7 4
1702356-19-1 C60H88ClN5O17 C26H38N2O10 538.595 7 38
1951439-51-2 C17H27NO5 C17H27NO5 325.405 3 3
2098982-00-2 C29H58N4O14 C24H48BrN3O11 634.563 19 11
2100306-58-7 C99H117N9O36 C34H39N3O10 649.698 3 35
2182601-74-5 C56H94N4O18 C24H39NO12 533.573 3 1
22273-77-4 ((but-3-yn-1-yloxy)methyl)benzene C11H12O 160.216 5 331
2353409-92-2 C93H125Cl2N11O33 C27H52N2O10 564.717 1 2
2363756-50-5 C56H86N8O15 C31H56N4O16 740.803 50 28
2401876-29-5 N-(3-aminopentynyl)-5,6-dihydro-11,12-didehydrodibenzo[b,f]azocin C20H20N2O 304.392 5 41
2514946-87-1 N-((1E,3E,5R,6R,9E,11Z,13E,14aS,16S,18aR)-6-((2R,3S,4R)-4-acetamido-3-hydroxypentan-2-yl)-2,5,12,14a-tetramethyl-8-oxo-5,8,14a,15,16,18a-hexahydro-6H-benzo[h][1]oxacyclohexadecin-16-yl)oct-7-ynamide C12H15NO4 237.255 2 2
2563873-82-3 C105H155FN12O38S C49H99N3O24 1114.33 11 29
2645443-13-4 (E)-cyclooct-2-en-1-yl (4-nitrophenyl) carbonate C15H17NO5 291.304 34 148
2765066-38-2 (3S)-3-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-2-[(3-amino-2,2-dimethyl-3-oxopropanoyl)amino]-3-(2H-tetrazol-5-yl)propanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-(2-fluorophenyl)-2-methylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-4-[[(1S)-1-[[4-[4-[4-[3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[[4-(157-azatricyclohexadeca-8(14),9(15),10(16),12(18),104,106(109)-hexaen-31-yn-157-yl)-4-oxobutanoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]butoxy]-2-ethyl-108-phenyl]phenyl]methyl]-2-[[(1S)-1-carbamoyl-4-(3,5-dimethylphenyl)butyl]amino]-2-oxoethyl]amino]-4-oxobutanoic acid C74H119N3O30 1530.76 3 9
2801772-87-0 C27H52N4O15 C25H44N4O13 608.643 2 1
406213-76-1 tert-butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate C19H37N3O8 435.518 34 33
53293-00-8 1-morpholinohex-5-yn-1-one C6H8O2 112.128 25 1545
56909-02-5 C11H16O3 C8H12O2 140.182 12 91

Last updated: July 27, 2026